6‐morpholino‐1,3,5‐triazine derivatives target CapZβ to inhibit endosomal trafficking and metastasis
نویسندگان
چکیده
منابع مشابه
Late Endosomal Cholesterol Accumulation Leads to Impaired Intra-Endosomal Trafficking
BACKGROUND Pathological accumulation of cholesterol in late endosomes is observed in lysosomal storage diseases such as Niemann-Pick type C. We here analyzed the effects of cholesterol accumulation in NPC cells, or as phenocopied by the drug U18666A, on late endosomes membrane organization and dynamics. METHODOLOGY/PRINCIPAL FINDINGS Cholesterol accumulation did not lead to an increase in the...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2021
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.2021.35.s1.05485